Looks like Lil Wayne is in big trouble, again. The rapper was indicted on felony drug and weapons charges on Friday. Wayne -- commonly known as one of the hardest working emcees -- was arrested in Yuma, Arizona, on January 22 after his tour bus was searched at a U.S. Border Patrol checkpoint and agents allegedly discovered marijuana, cocaine, ecstasy and a .40-caliber pistol.

The rapper, whose real name is Dwayne Michael Carter Jr., was charged with one count each of possession of a narcotic drug for sale, possession of dangerous drugs, misconduct involving weapons and one count of possession of drug paraphernalia. Carter pleaded not guilty to the laundry list of charges. He's due back in court on March 7.

In the meantime, the 25-year-old rapper is set to return to his hometown of New Orleans to perform with Juvenile and B.G. -- formerly known as the Hot Boys -- for the first time in seven years as part of the NBA All-Star Weekend festivities on Sunday. But if birds of a feather indeed flock together, that would explain Juvenile's latest legal woes.

The New Orleans-bred rapper -- born Terius Grey -- was arrested for misdemeanor marijuana possession in Mississippi on Tuesday. Grey was pulled over while driving with an expired tag on Interstate 20 in Meridian, Mississippi. Officials searched the rapper's vehicle and "a small amount of marijuana was seized," according to Lauderdale County Sheriff William Sollie.